NeuroD1 Antibody, Biotin Conjugated

Basic informations

  • Size: 0.1ml
  • Catalog number: bs-1517R-Biotin
  • Price: 333.00EUR
NeuroD1 Antibody, Biotin Conjugated

Long name

NeuroD1 Polyclonal Antibody, Biotin Conjugated

Category

Conjugated Primary Antibodies

Conjugation

Biotin

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

NeuroD1

Specificity

This is a highly specific antibody against NeuroD1.

Modification

Unmodified

Modification site

None

Clonality

Polyclonal

Clone

Polyclonal antibody

Concentration

1ug per 1ul

Immunogen_range

1-50/356

Subcellular location

Cytoplasm, Nucleus

Source

KLH conjugated synthetic peptide derived from human NeuroD1

Gene ID number

4760

Swiss Prot

Q13562

Tested applications

WB, IHC-P

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500)

Crossreactivity

Human, Mouse, Rat

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Antigen background

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Purification method

This antibody was purified via Protein A.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Excitation Emission

N/A

Synonyms

BETA2; BHF-1; MODY6; NEUROD; bHLHa3; Neurogenic differentiation factor 1; NeuroD1; Class A basic helix-loop-helix protein 3

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.

Additional conjugation

Biotinylated

French translation

anticorps