Activated Notch1 Antibody, Cy7 Conjugated

Basic informations

  • Size: 0.1ml
  • Catalog number: bs-20252R-Cy7
  • Price: 350.00EUR
Activated Notch1 Antibody, Cy7 Conjugated

Long name

Activated Notch1 Polyclonal Antibody, Cy7 Conjugated

Category

Conjugated Primary Antibodies

Conjugation

Cy7

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

Neurogenic locus notch homolog protein 1

Specificity

This is a highly specific antibody against Neurogenic locus notch homolog protein 1.

Modification

Unmodified

Modification site

None

Clonality

Polyclonal

Clone

Polyclonal antibody

Concentration

1ug per 1ul

Immunogen_range

1754-1780/2555

Source

KLH conjugated synthetic peptide derived from human Notch 1 intracellular domain.

Gene ID number

4851

Swiss Prot

P46531

Tested applications

IF(IHC-P)

Recommended dilutions

IF(IHC-P)(1:50-200)

Crossreactivity

Human

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Antigen background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Purification method

This antibody was purified via Protein A.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Excitation Emission

743nm/767nm

Synonyms

hN1; AOS5; TAN1; AOVD1; Neurogenic locus notch homolog protein 1; Notch 1; Translocation-associated notch protein TAN-1; NOTCH1

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Conjugated

These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.

Additional conjugation

Cy7

French translation

anticorps