Available ordering format
Lyophilized
Immunogen
A synthetic peptide as a part of human BDNF protein, conjugated to KLH. The BDNF protein sequence is highly conserved amongst primates.
Raised in
Rabbit
Clonality
Polyclonal
Clone
Polyclonal
Purification
Serum
How to reconstitute
For reconstitution add 100 µl of sterile water.
Storage condition
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Verified applications
Immunohistochemistry (IHC), ELISA, Western blot (WB).
Connected products
AS16 3242 | BDNF | Brain Derived Neurotrophic Factor (affinity purified)
Recommended dilutions for use
A working dilution of 1:1000 to 1:2000 is recommended for the tested applications. Optimal dilutions/concentrations should be determined by the end user.
Molecular weight (expected | аpparent)
see datasheet
Verified reactivity
rat, mouse, human
Possible reactivity
to be determined
No reactivity
no confirmed exceptions from predicted reactivity known in the moment
Supplementary information
to be added when available
References
to be added when available
Scientific context
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. It promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binds to NTRK2/TRKB. It is converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.
Notes
None
Protein number
Refer to NCBI
TAIR number
Refer to NCBI
Tissue
brain
Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.