A synthetic peptide corresponding to a sequence in the middle region of human Neuropilin 1(211-230aa LEIWDGFPDVGPHIGRYCGQ), different from the related rat and mouse sequences by one amino acid.
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
Storage condtions
Keep the Neuropilin 1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
Tips
The Neuropilin 1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
Background
NRP1(Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor(VEGF) and semaphorin(see SEMA3A) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10.They localized the NRP1 gene to 10p12 using radiation hybrid mapping. Sulfation of the glucosamine-O-6 and iduronic acid-O-2 groups of heparin potentiated PGF2 binding to NRP1. NRP1 also bound PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.
Related articles
1. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D. W., Schmitz, J. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immun. 165: 6037-6046, 2000. 2. Fujisawa, H., Ohtsuki, T., Takagi, S., Tsuji, T. An aberrant retinal pathway and visual centers in Xenopus tadpoles share a common cell surface molecule, A5 antigen. Dev. Biol. 135: 231-240, 1989. 3. Rossignol, M., Gagnon, M. L., Klagsbrun, M. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. Genomics 70: 211-222, 2000.
Gene Name
NRP1
Protein Name
Neuropilin-1
Gene Full Name
neuropilin 1
Synonyms
A5 protein antibody|BDCA4 antibody|BLOOD DENDRITIC CELL ANTIGEN 4 antibody|CD 304 antibody|CD304 antibody|DKFZp686A03134 antibody|DKFZp781F1414 antibody|NEL like protein 1 antibody|Nel related protein 1 antibody|Neuropilin-1 antibody|Neuropilin1 antibody|Neuropilin1 transmembrane receptor antibody|NP1 antibody|NPN1 antibody|NRP 1 antibody|NRP antibody|NRP1 antibody|NRP1_HUMAN antibody|OTTHUMP00000020818 antibody|OTTHUMP00000020820 antibody|OTTHUMP00000020821 antibody|Vascular endothelial cell growth factor 165 receptor antibody|VEGF165R antibody
Uniprot ID
O14786
Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
