anti-Neurofilament NF-H Antibody [NAP4]

Gene info

Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease.

Gene names

NFH, KIAA0845, NFH, 200 kDa neurofilament protein, NF-H

Antibodie's label

unlabelled serum

Purity

Total IgG fraction

Ab raised in

Mouse

Type

Monoclonal

Monoclonal

NAP4

Spicific to

Specific for the ~200k Neurofilament H protein. It recognizes phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species there is some cross-reactivity with the related phosphorylated KSP sequences found in the related neurofilament subunit NF-M. It recognizes neurofilaments in frozen sections in tissue culture and in formalin fixed sections.

Antigen

Purified bovine NF-H.

Immuno application

Western Blot, immuno-histo-chemistry

Keep at

Neurofilament NF-H antibody can be stored at -20 grades C and is stable at -20 grades C for at least 1 year.

Works with

Chicken, Mammal

Omim nr

226726294

Ncbi nr

P12036

KDa

200

Vial with antibody

in solution

NCBI GENE nr

4744

GENE symbol

NEFH

Antigene name

neurofilament, heavy polypeptide

Source

Homo sapiens

Protein nr

P12036

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps