Gene info
The recently isolated neurofibromatosis 2 tumor suppressor gene encodes a 595 amino acid protein (Merlin). The protein product Merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumor suppressor whose absence results in the occurrence of multiple tumors of the nervous system, particularly schwannomas and meningiomas. Merlin's similarity to ERMs suggests that it might share functions, acting as a link between cytoskeletal components and the cell membrane. The NF2 protein is highly expressed in human fibroblasts and is detected as a single band of about 75 kDa. This antibody is specific for the phosphorylated form of human NF2 (Merlin).
Gene names
NF2, ACN, BANF, Moesin-ezrin-radixin like, Neurofibromin 2 (merlin), Neurofibromin-2, SCH, Merlin, Schwannomerlin, Schwannomin
Antibodie's label
unlabelled serum
Purity
Immunoaffinity Chromatography
Ab raised in
Rabbit
Type
Polyclonal
Spicific to
pSer518
Antigen
Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).
Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno precipitation
Antibody advice
Neurofibromin 2 antibody can be used in ELISA, and immunohistochemistry starting at 2.5 ug/mL.
Suspention, pH, azide
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Keep at
Store Neurofibromin 2 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
Works with
Human, Mouse
Omim nr
462594
Ncbi nr
P35240
Vial with antibody
in solution
NCBI GENE nr
4771
GENE symbol
NF2
Antigene name
neurofibromin 2 (merlin)
Source
Homo sapiens
Protein nr
P35240
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps