Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2). Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2). NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4). NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5).
Gene names
Neuroligin 2
Antibodie's label
unlabelled serum
Purity
NLGN2 antibody is affinity chromatography purified via peptide column.
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Spicific to
NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.
Antigen
NLGN2 antibody was made against a 19 amino acid peptide near the carboxy terminus of human NLGN2.
Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
Antibody advice
NLGN2 antibody can be used for detection of NLGN2 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
Suspention, pH, azide
NLGN2 antibody is supplied in PBS containing 0.02% sodium azide.
Keep at
NLGN2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
Works with
Human, Mouse, Rat
Omim nr
30840978
Ncbi nr
NP_065846
KDa
Predicted: 92, 99 kDa Observed: 80, 97 kDa
Vial with antibody
in solution
Quantity per ml
1 mg/mL
NCBI GENE nr
57555
GENE symbol
NLGN2
Antigene name
neuroligin 2
Source
homo sapiens
Protein nr
Q8NFZ4
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
