Neurotensin Receptor 2 Antibody, ALEXA FLUOR 555

Basic informations

  • Size: 100ul
  • Catalog number: bs-12004R-A555
  • Price: 380.00EUR
Neurotensin Receptor 2 Antibody, ALEXA FLUOR 555

Long name

Neurotensin Receptor 2 Antibody, ALEXA FLUOR 555 Conjugated

Also known as

Anti-Neurotensin Receptor 2 PAb ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Conjugated with

ALEXA FLUOR® 555

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

Neurotensin Receptor 2

Specificity

This is a highly specific antibody against Neurotensin Receptor 2.

Modification

Unmodified

Modification Site

None

Clonality

Polyclonal

Clone

Polyclonal antibody

Concentration

1ug per 1ul

Subcellular location

Extracellular

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Neurotensin Receptor 2

Tested applications

FCM, IF(IHC-P)

Recommended dilutions

FCM(1:20-100), IF(IHC-P)(1:50-200)

Crossreactivity

Human, Mouse, Rat

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Background of the antigen

Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1beta and TNF?in an ERK1/2 and Akt kinase-dependent manner.

Purification

Purified by Protein A.

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Excitation emission

553nm/568nm

Synonyms

Levocabastine sensitive neurotensin receptor; Levocabastine-sensitive neurotensin receptor; Neurotensin receptor type 2; NT R 2; NT-R-2; NTR2; NTR2 receptor; NTR2_HUMAN; Ntsr2.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

French translation

anticorps