Recombinant Human GDNF Receptor α-2/GFRA2 Protein(C-Fc-6His)

Basic informations

  • Size: 10µg
  • Catalog number: PKSH032482-10µg
  • Price: 156.00EUR
Recombinant Human GDNF Receptor α-2/GFRA2 Protein(C-Fc-6His)

Synonym

GDNFR-beta;Neurturin receptor alpha;RET ligand 2;TGF-beta-related neurotrophic factor receptor 2;GDNFRB; RETL2; TRNR2

Activity

NA

Sequence

Ser22-Ser441

Fusion tag

C-Fc-6His

Accession

O00451

Expressed Host

Human cells

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Purity

>95% as determined by reducing SDS-PAGE.

Endotoxin

<1.0 EU per µg as determined by LAL test.

Stability and Storage

Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

Mol Mass

74.7 kDa

AP Mol Mass

120 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.

Background

GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Source

Recombinants or rec. proteins

Group

recombinants